FIGURE 2.

RBP functions in the chromatin-based DSB response. Many RNA-binding proteins (RBPs) associate with DNA double-strand breaks (DSBs) and the surrounding chromatin where they carry out several distinct functions. First, they promote the recruitment or modulate the activities of DSB signaling and repair factors. Second, they regulate local chromatin remodeling. Third, they contribute to liquid-liquid phase separation around the break site. Fourth, they prevent, resolve or stabilize RNA:DNA hybrids and R-loops. Fifth, they participate in the generation or processing of various non-coding RNA species at DSB sites.