FIGURE 12.

Putative model on YchF-dependent regulation of lmRNA translation. YchF promotes binding of IF3 to the 30 S ribosomal subunit and prevents binding of IF3 to the 50 S ribosomal subunit. This favors the translation of canonical mRNAs. When cells encounter stress or enter the stationary phase, the YchF levels gradually decrease, which allows binding of IF3 to the 50 S subunit, which in turn increases the translation of lmRNAs encoding stress response proteins and allows cell survival under stress conditions.