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. 2021 May 7;12:639628. doi: 10.3389/fphar.2021.639628

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Copyright © 2021 Rahman, Hannan, Dash, Rahman, Islam, Uddin, Sohag, Rahman and Rhim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oxyresveratrol controls the autophagy-apoptosis signal to modulate neuroblastoma cells. OxyR activates PI3K/Akt/mTOR and the inhibition of mTOR by rapamycin blocks autophagy, indicating an mTOR-dependent autophagic pathway. OxyR led to arrest at the G2/M phase of the cell cycle and activated mitochondria-mediated caspase-3 dependent apoptosis. OxyR was also revealed to increase Bax/Bcl-2 ratio without generating ROS or activating p53. When the p38 inhibitor, SB203580, was applied, OxyR was found to activate autophagy-apoptosis signaling in neuroblastoma cells.