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. 2021 May 7;12:662173. doi: 10.3389/fphar.2021.662173

FIGURE 3.

FIGURE 3

Passive Avoidance Learning results of rats treated with icv. streptozotocin (STZ) or citrate buffer (control). Columns show means ± SEM values of entry latencies, numbers inside the columns indicate the not entered/total number of animals. (A) Results of experiment 1 (EXP1), when the animals received 2 × 1.5 mg/kg icv. STZ 11 weeks before the test. No significant difference was observed between control and STZ-treated animals (unpairedt-test acquisition trial: t(15) = −0.23, ns; unpaired t-test retention trial: t(15) = −0.45, ns; Fischer exact p, two tailed test p = 1.0, ns). (B) Results of experiment 2 (EXP2), when the animals received 3 × 1.5 mg/kg icv. STZ 6 weeks before the test. No significant difference was observed between control and STZ-treated animals (unpaired t-test acquisition trial: t(22) = 0.85, ns; unpaired t-test retention trial: t(22) = −1.10, ns; Fischer exact two tailed test p = 3707).