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. 2021 May 7;12:615998. doi: 10.3389/fphar.2021.615998

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Copyright © 2021 Zhu, Wang, Xie, Meng, Feng, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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R1 reduces the infarction volume and neuronal loss in rats subjected to MCAO. R1 and edaravone were both intraperitoneally injected immediately after MCAO surgery (A) Effects of R1 on infarction volumes (n = 5) (B) Quantitative analysis of cerebral infarct volumes (C) H&E staining and Nissl staining of the cortex and hippocampal CA1 regions of each group (n = 5) (D) Relative density (% of sham) of the H&E and Nissl staining in the cortex and hippocampal CA1 regions in all the groups. Scale bar = 200 μm. Data are expressed as the mean ± SD and were analyzed by ANOVA. ^# p< 0.05 and ^## p< 0.01 vs. Sham group; *p< 0.05 and **p< 0.01 vs. MCAO/R group.