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. 2021 May 7;12:615998. doi: 10.3389/fphar.2021.615998

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Copyright © 2021 Zhu, Wang, Xie, Meng, Feng, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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R1 restores long-term neurological function in rats subjected to MCAO. The behavioral tests were conducted on days 1, 7, 14, 21 and 28 after MCAO surgery (A) Zea-Longa score (B) cylinder tests (C) novel object recognition tests on day 28 after MCAO surgery (D) The body weight of the rats in each treatment group over 28 days. Data are expressed as the mean ± SD and were analyzed by ANOVA. ^# p< 0.05 and ^## p< 0.01 vs. Sham group; *p< 0.05 and **p< 0.01 vs. MCAO/R group.