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. 2021 May 7;12:615998. doi: 10.3389/fphar.2021.615998

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Copyright © 2021 Zhu, Wang, Xie, Meng, Feng, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the mechanisms underlying the R1-induced promotion of neurological recovery after ischemia-reperfusion injury. Overall, R1 enhances neurogenesis and oligodendrogenesis by promoting NPC proliferation, migration and the survival of newborn neurons. Therefore, R1 stimulates the expression of neural synaptic factors and facilitates the release of neurotransmitters. R1 activates the BDNF/Akt/CREB signaling pathway, thereby accelerating neurogenesis to promote neurological recovery.