Table 1.
Demographics.
| Demographics | |||
|---|---|---|---|
| Study cohort N = 353 | Excluded cohort (Infants with HUS performed DOL 0-2) N = 230 | P value | |
| Birth gestational age, weeks (mean, SD) | 28.89 (2.02) | 26.82 (2.45) | <.0001 |
| 23 weeks (n, %) | 3 (0.8) | 18 (7.8) | <.00001 |
| 24 weeks (n, %) | 13 (3.7) | 30 (13.0) | <.00001 |
| 25 weeks (n, %) | 13 (3.7) | 27 (11.7) | .0002 |
| 26 weeks (n, %) | 17 (4.8) | 39 (17.0) | <.00001 |
| 27 weeks (n, %) | 33 (9.3) | 24 (10.4) | .666 |
| 28 weeks (n, %) | 45 (12.7) | 25 (10.9) | .495 |
| 29 weeks (n, %) | 62 (17.6) | 28 (12.2) | .078 |
| 30 weeks (n, %) | 88 (24.9) | 18 (7.8) | <.00001 |
| 31 weeks (n, %) | 66 (18.7) | 16 (7.0) | .0001 |
| 32 weeks (n, %) | 13 (3.7) | 4 (1.7) | .173 |
| Birth weight, grams (mean, SD) | 1214.54 (323.82) | 967.80 (348.39) | <.0001 |
| Male/Total (n, %) | 194 (55.0) | 123 (53.5) | .726 |
| Race (n, %): | .030 | ||
| Black | 47 (13.3) | 46 (20.0) | |
| White | 284 (80.5) | 168 (73.0) | |
| Asian | 14 (4.0) | 5 (2.2) | |
| Other | 8 (2.3) | 11 (4.8) | |
| Rate of antenatal steroids (n, %) | 332 (94.1) | 205 (89.1) | .031 |
| Bacterial sepsis, on or before DOL3 (n, %) | 3 (0.8) | 3 (1.3) | .595 |
| Sepsis or meningitis, late after DOL3 (n, %) | |||
| Bacterial (n, %) | 10 (2.8) | 30 (13.0) | <.00001 |
| Coagulase negative staph (n, %) | 6 (1.7) | 7 (3.0) | .283 |
| Fungal (n, %) | 1 (0.3) | 2 (0.9) | .333 |
| Any respiratory support at 36 weeks (Chronic Lung disease) (n, %) | 67 (19.0) | 98 (42.6) | <.00001 |
| Mechanical ventilation | 3 (0.8) | 7 (3.0) | .046 |
| High frequency oscillatory ventilation | 1 (0.3) | 0 | .419 |
| High flow nasal canula | 18 (5.1) | 47 (20.4) | <.00001 |
| Noninvasive positive pressure ventilation | 5 (1.4) | 8 (3.5) | .099 |
| Continuous positive airway pressure | 8 (2.3) | 6 (2.6) | .792 |
| Oxygen at discharge | 31 (8.8) | 48 (20.9) | <.00001 |
| Steroids for chronic lung disease (n, %) | 28 (7.9) | 58 (25.2) | <.00001 |
| Necrotizing enterocolitis (NEC) (n, %) | 20 (5.7) | 19 (8.3) | .220 |
| Surgery for NEC, suspected NEC, or bowel perforation (n, %) | 5 (1.4) | 10 (4.3) | .029 |
| Hypoxic-ischemic encephalopathy (n, %) | 0 | 0 | |