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. 2021 May 19;14:11786469211016474. doi: 10.1177/11786469211016474

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Tryptophan-Kynurenine pathway.

Abbreviations: 3HAA, 3-hydroxyanthranilic acid; 3HAO, 3-hydroxyanthranilate 3,4-dioxygenase; 3HK, 3-hydroxykynurenine; AA, anthranilic acid; BH2, 7,8-dihydroneopterin; BH4, tetrahydrobiopterin; KAT, kynurenine aminotransferase; KMO, kynurenine 3-monooxygenase; Kyn, kynurenine; KYNA, kynurenic acid; Kynase, kynureninase; NAD, nicotinamide adenine dinucleotide; neo, neopterin; QUIN, quinolinic acid; TDO/IDO, tryptophan- and indoleamine-2,3-dioxygenases; Trp, tryptophan; XA, xanthurenic acid.

*Kinetic Michaelis-Menten constants (µmol).