TABLE 1.

The alignment scores computed for the PDB sequence 6DRX and 3NYA using a miss and gap score of −2.

Target protein	Reference protein	8DP BLOSUM min:−0.84 max: 0.73	8DP GPCRtm min:−0.83 max: 0.75	10DP BLOSUM min:−0.77 max: 0.66	10P GPCRtm min: −0.97 max: 0.66
5HT2B/H8G (PDB ID: 6DRX)	ADRB2/JTZ (PDB ID: 3NYA)	0.39	0.4	0.54	0.46
ADRB2/JTZ (PDB ID: 3NYA)	5HT2B/H8G (PDB ID: 6DRX)	0.36	0.37	0.52	0.43

The highest and lowest values for each profiling scoring function obtained by aligning all the diverse GPCRs available in the PDB databank are also reported.