Table 3.

Association between ICAS burden and presence of brain infarcts (yes vs. no).

	Model	Large subcortical/cortical infarctsbRR (95% CI)	LacunesRR (95% CI)	Cerebellar infarctsRR (95% CI)	CorticalmicroinfarctsRR (95% CI)
ICAS burdena	1	1.71 (1.34–2.19)	1.50 (1.19–1.89)	1.28 (0.87–1.86)	1.62 (1.29–2.03)
	2	1.65 (1.12–2.43)	1.45 (1.14–1.86)	1.15 (0.78–1.70)	1.48 (1.13–1.94)
	3	1.56 (1.12–2.27)	1.41 (1.10–1.82)	1.10 (0.72–1.70)	1.43 (1.07–1.94)

Notes: Values are relative risks (RR) with 95% confidence intervals calculated with modified Poisson regression analysis with robust error variance.

Model 1: adjusted for age and sex. Model 2: model 1 + adjustment for educational level, body mass index, smoking pack-years, alcohol use, diabetes, systolic/diastolic blood pressure, total cholesterol level, total high-density lipoprotein level, and use of antihypertensive, lipid-lowering, antiplatelet, or oral anticoagulant medication. Model 3: model 2 + adjustment for carotid stenosis ≥50%, carotid intima-media thickness, or ankle–brachial index.

^aStandardized into Z-score.

^bDefined as presence of large subcortical infarcts and/or cortical infarcts.