Table 4.

Association between ICAS burden and presence of cerebral microbleeds (yes vs. no).

	Model	Any microbleedRR (95% CI)	Lobar microbleedsRR (95% CI)	Deep microbleedsRR (95% CI)
ICAS burdena	1	1.04 (0.89–1.21)	1.03 (0.86–1.23)	1.14 (0.91–1.42)
	2	1.09 (0.92–1.29)	1.10 (0.90–1.34)	1.18 (0.92–1.51)
	3	1.10 (0.93–1.30)	1.11 (0.91–1.35)	1.19 (0.92–1.54)

Notes: Values are relative risks (RR) with 95% confidence intervals calculated with modified Poisson regression analysis with robust error variance.

Model 1: adjusted for age and sex. Model 2: model 1 + adjustment for educational level, body mass index, smoking pack-years, alcohol use, diabetes, systolic/diastolic blood pressure, total cholesterol level, total high-density lipoprotein level, and use of antihypertensive, lipid-lowering, antiplatelet, or oral anticoagulant medication. Model 3: model 2 + adjustment for carotid stenosis ≥50%, carotid intima-media thickness, or ankle–brachial index.

^aStandardized into Z-score.