Table 5.

Association between ICAS burden and brain volumes and cerebral blood flow.

	Model	Total brain volume (ml)b (95% CI)	Total WMHvolume (ml)bb (95% CI)	Periventricular WMH volume (ml)bb (95% CI)	Deep WMH volume (ml)bb (95% CI)	Cerebral blood flow (ml/min)cb (95% CI)
ICASburdena	1	0.34 (−5.05 to 5.73)	0.24 (0.04 to 0.43)	0.31 (0.1 to 0.52)	0.02 (−0.21 to 0.25)	−15.62 (−32.97 to 1.72)
	2	1.99 (−4.01 to 7.98)	0.24 (0.02 to 0.46)	0.32 (0.08 to 0.56)	0.01 (−0.26 to 0.26)	−15.24 (−34.85 to 4.38)
	3	2.14 (−3.92 to 8.2)	0.25 (0.03 to 0.48)	0.33 (0.10 to 0.57)	0.01 (−0.26 to 0.27)	−12.39 (−31.87 to 7.09)

Values are unstandardized linear regression coefficients (b) with 95% confidence intervals calculated with standard linear regression analysis.

Model 1: adjusted for age and sex. Model 2: model 1 + adjustment for educational level, body mass index, smoking pack-years, alcohol use, diabetes, systolic/diastolic blood pressure, total cholesterol level, total high-density lipoprotein level, use of antihypertensive, lipid-lowering, antiplatelet or oral anticoagulant medication. Model 3: model 2 + adjustment for carotid stenosis ≥50%, carotid intima-media thickness or ankle–brachial index.

^aStandardized into Z-score.

^bNatural-log transformed.

^cAnalyses of cerebral blood flow were additionally adjusted for total brain volume in all models.WMH: white matter hyperintensities.