Table 2.

Univariate and multivariate analysis of risk factors for clinical outcomes.

	II-IV GVHD						III-IV GVHD						CIR						NRM						LFS
	Univariate			Multivariate			Univariate			Multivariate			Univariate			Multivariate			Univariate			Multivariate			Univariate			Multivariate
	HR	95% Cl	p value	HR	95% Cl	p value	HR	95% Cl	p value	HR	95% Cl	p value	HR	95% Cl	p value	HR	95% Cl	p value	HR	65% Cl	p value	HR	65% Cl	p value	HR	65% Cl	p value	HR	65% Cl	p value
Age(≥14 vs. <14yrs)	0.785	0.395-1.56	0.49				0.339	0.0921-1.25	0.088	0.506	0.1081-2.37	0.39	1.23	0.418-3.62	0.708				2.09	0.89-4.91	0.084				1.8	0.921-3.51	0.079	1.652	0.84-3.25	0.15
Treatment pre-HSCT (CAR-T vs. control)	2.36	1.18-4.75	0.016				0.956	0.263-3.47	0.945				0.873	0.241-3.17	0.836				0.791	0.295-2.12	0.641				0.827	0.38-1.8	0.631
Disease status(≥CR2 vs. CR 1)	1.09	0.557-2.15	0.769				0.494	0.152-1.6	0.239				3.87	1.09-13.7	0.027	4.1	1.13-14.84	0.031	0.774	0.344-1.74	0.54				1.54	0.808-2.93	0.192
MRD(pos vs. neg)	1.09	0.536-2.23	0.81				2.29	0.75-7.02	0.142				2.81	0.961-8.24	0.056	3.02	1.02-8.96	0.046	1.45	0.638-3.32	0.38				2.21	1.16-4.24	0.017	2.105	1.09-4.06	0.027
Poor risk chromosomes (yes vs. no)	1.5	0.76-2.95	0.245				2.48	0.735-8.17	0.125				0.709	0.236-2.13	0.543				0.622	0.263-1.47	0.271				0.614	0.313-1.21	0.151
Conditioning(TBI-based vs. Bu-based)	0.888	0.365-2.16	0.795				0.254	0.0815-8.17	0.015	0.387	0.0929-1.61	0.19	0.655	0.181-2.38	0.523				0.937	0.314-2.79	0.903				0.883	0.384-2.03	0.765
Donor type (haplo vs. MUD/MSD)	0.894	0.45-1.78	0.753				3.17	0.715-14	0.113				1.33	0.413-4.31	0.629				0.917	0.402-2.09	0.84				1.25	0.646-2.42	0.516
donor-recipients gender matched(female to male vs. others)	1.16	0.464-2.89	0.761				3.37	1.07-10.6	0.0375	1.885	0.4163-8.54	0.41	1.15	0.271-4.89	0.853				0.586	0.142-2.42	0.457				0.61	0.234-1.59	0.33
course from diagnosis to transplant (≥ median vs. <median)	0.883	0.45-1.73	0.719				0.455	0.141-1.47	0.188				2.34	0.732-7.48	0.144				0.6	0.262-1.37	0.225				1.05	0.552-1.98	0.893
MNC (≥median vs. <median)	0.59	0.303-1.15	0.3				0.996	0.351-2.82	0.934				1.11	0.412-3	0.886				0.926	0.433-1.98	0.871				1.12	0.62-2.01	0.616
CD3 (≥median vs. <median)	1.17	0.596-2.29	0.655				0.713	0.228-2.23	0.561				0.421	0.13-1.36	0.137				1.13	0.506-2.53	0.766				0.824	0.432-1.57	0.559
CD34 (≥median vs. <median)	1.01	0.511-1.98	0.986				0.682	0.219-2.12	0.51				0.413	0.129-1.32	0.128				0.916	0.408-2.06	0.834				0.576	0.303-1.1	0.096	0.644	0.34-1.22	0.18
cGVHD (limited vs. extensive vs.