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. 2021 May 7;12:669146. doi: 10.3389/fphar.2021.669146

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Copyright © 2021 Zheng, Yang, Zhang, Yang, Fan, Li, Zhai, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of miR-327 on the FGF10/Akt/Nrf2 signaling pathway in MI/RI rats. FGF10 mRNA and protein levels were measured by qRT-PCR and the Western blot analysis in MI/RI rats heart tissues (A-B). The proteins of p-PI3K and t- PI3K, t-Akt and p-Akt, nucleus Nrf2, HO-1, Bax, Bcl-2, Cyt-c, cleaved caspase-9, and cleaved caspase-3 in heart tissues were detected by the Western blot analysis (C). Data are expressed as the mean ± SD (n = 3); #p < 0.05 versus the Sham group; *p < 0.05 versus the Ad-NC group.