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. 2021 May 7;12:669146. doi: 10.3389/fphar.2021.669146

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Copyright © 2021 Zheng, Yang, Zhang, Yang, Fan, Li, Zhai, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of downregulation of miR-327 on the FGF10/Akt/Nrf2 signaling pathway in TBHP-treated H9c2 cells. FGF10 mRNA and protein levels were detected by qRT-PCR and Western blot analysis after TBHP treatment (A, B). Downstream protein p-PI3K and t-PI3K, t-Akt and p-Akt, antioxidant-related protein nucleus Nrf2, and HO-1 were measured by the Western blot analysis in H9c2 cells (C). Data are expressed as the mean ± SD (n = 3); #p < 0.05 versus the Control group; *p < 0.05 versus the Ad-NC group.