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. 2021 May 7;12:669146. doi: 10.3389/fphar.2021.669146

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Copyright © 2021 Zheng, Yang, Zhang, Yang, Fan, Li, Zhai, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of miR-327 on oxidative stress in MI/RI rats. Representative images of immunofluorescence microscopy after transfection of recombinant adenovirus or NS injection, DAPI-labeled nuclei of cardiomyocytes (blue), EGFP(green) and merged (A). Relative expression of miR-327 in MI/RI rats (B). The levels of SOD (C), GSH-Px (D), and MDA (E) in heart tissues of MI/RI rats. DHE staining for detecting intracellular ROS generation in heart tissues of MI/RI rats (G) in each group, and the analysis of ROS positive cells by Image-Pro Plus (F). Data are expressed as the mean ± SD (n = 4); #p < 0.05 versus the Sham group; *p < 0.05 versus the Ad-NC group.