Fig. 5.

Elevated peripheral blood markers are associated with enhanced Treg function. Correlation analyses are depicted for the dependent variables including AUC for Treg activity and (a) %Integrin B7+CD4+ T cells, (b) %FOXP3+CD4+ T cells, (c) %FAS+CD4+ T cells, (d) %CD45RA-RO+CD4+ T cells, (e) %CD27+CCR7- Treg, (f) %Integrin B7+ Treg, (g) %Integrin A4B7+ Treg, and (h) %CD45RA-CD27+CCR7- Treg. For all correlation analyses, regression bands are indicated by dashed lines that encompass the 95% confidence intervals (red) and 95% prediction values (blue). Pearson r and p values are depicted on individual graphs. Data are displayed as scatter plots using the percentage of peripheral blood marker in either the total CD4 population or the Treg population against Treg activity, AUC. Correlations were determined using Pearson product–moment correlation coefficients, p values determined for correlation coefficients greater than 0.25, and the resulting 16 determinations adjusted for FDR. Best-fit lines were determined by linear regression.