Fig. 6.

Elevated peripheral blood markers and enhanced Treg function are associated with decreased UPDRS Part III scores. Correlation analyses for the dependent variables that included UPRS Part III scores and (a) %FAS+ CD4+ T cells, (b) %Integrin B7+ Tregs, (c) %CD45RA+CD27+CCR7- Tregs, (d) %CD27+CCR7- Tregs, and (e) Treg activity as determined by 50% Inhibitory Treg number. For all correlation analyses, regression bands are indicated by dashed lines that encompass the 95% confidence intervals (red) and 95% prediction values (blue). The Pearson r and p values are depicted on individual graphs. Data are displayed as scatter plots using the percentage of peripheral blood marker in total CD4 population, Treg population, or Treg function as determined about 50% inhibitory Treg number against UPDRS Part III scores. Correlations were determined using Pearson product-moment correlation coefficients, p values determined for correlation coefficients greater than 0.25, and the resulting 39 determinations adjusted for FDR. Best-fit lines were determined using linear regression.