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. 2021 May 7;11:682088. doi: 10.3389/fonc.2021.682088

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Copyright © 2021 Wichmann, Willner, Kuhnt, Kluge, Gradistanac, Wald, Fest, Lordick, Dietz, Wiegand and Zebralla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier cumulative survival (KM) plots for overall survival (OS) of squamous cell carcinoma of unknown primary patients (NSCCUP-P) demonstrate the improved outcome achieved by standardized treatment including neck dissection (ND) and cisplatin-based radio-chemotherapy (Cis+) for NSCCUP-P with extracapsular extension of neck nodes (ECE). Besides KM plots, the numbers of patients and events are shown with 75th percentile and median along with their respective 95% confidence interval (95% CI) together with P-values from pairwise comparisons in various strata combining ND, ECE and Cis in cohorts 1 and 2 as well as for all NSCCUP-P.