Table 1.
Clinical and epidemiological characteristics, diagnostic procedures and treatment of neck squamous cell carcinoma of unknown primary (NSCCUP) patients of cohorts 1 and 2.
| Clinical and epidemiological characteristics | Total | Cohort 1 n (%) |
Cohort 2 n (%) |
P value# | |||
|---|---|---|---|---|---|---|---|
| Sex | female | 15 | 7 | (13.2) | 8 | (12.9) | 0.961 |
| male | 100 | 46 | (86.8) | 54 | (87.1) | ||
| Age at diagnosis | < 60 years | 66 | 32 | (60.4) | 34 | (54.8) | 0.549 |
| ≥ 60 years | 49 | 21 | (39.6) | 28 | (45.2) | ||
| N-category TNM 2010 | N1 | 17 | 8 | (15.1) | 9 | (14.5) | 0.555 |
| N2a | 31 | 16 | (30.2) | 15 | (24.2) | ||
| N2b | 35 | 12 | (22.6) | 23 | (37.1) | ||
| N2c | 6 | 3 | (5.7) | 3 | (4.8) | ||
| N3 | 26 | 14 | (26.4) | 12 | (19.4) | ||
| N-category TNM 2017 | N1 | 22 | 8 | (15.1) | 14 | (22.6) | 0.494 |
| N2 | 1 | – | 1 | (1.6) | |||
| N2a | 15 | 9 | (17.0) | 6 | (9.7) | ||
| N2b | 13 | 7 | (13.2) | 6 | (9.7) | ||
| N2c | 2 | – | 2 | (3.2) | |||
| N3a | 3 | 2 | (3.8) | 1 | (1.6) | ||
| N3b | 59 | 27 | (50.9) | 32 | (51.6) | ||
| p16 IHC | positive | 10 | – | 10 | (16.1) | 4.60 × 10−6 | |
| negative | 13 | – | 13 | (21.0) | |||
| unknown | 92 | 53 | (100) | 39 | (62.9) | ||
| HR-HPV DNA | positive | 10 | – | 10 | (16.1) | 8.92 × 10−6 | |
| negative | 12 | – | 12 | (19.4) | |||
| unknown | 93 | 53 | (100) | 40 | (64.5) | ||
| Tobacco smoking | never | 27 | 13 | (24.5) | 14 | (22.6) | 0.405 |
| former | 26 | 9 | (17.0) | 17 | (27.4) | ||
| current | 62 | 31 | (58.5) | 31 | (50.0) | ||
| Alcohol | never | 24 | 9 | (17.0) | 15 | (24.2) | 0.563 |
| former | 12 | 5 | (9.4) | 7 | (11.3) | ||
| current | 79 | 39 | (73.6) | 40 | (64.5) | ||
| Alcohol per day | 0 | 24 | 9 | (17.0) | 15 | (24.2) | 0.431 |
| 1–30 g | 36 | 15 | (28.3) | 21 | (33.9) | ||
| 31–60 g | 22 | 10 | (18.9) | 12 | (19.4) | ||
| >60 g | 33 | 19 | (35.8) | 14 | (22.6) | ||
#P value from Pearson’s Chi-square (χ2) tests; p16 IHC, detection of ≥70% p16INK4A expressing cells in immunohistochemistry (IHC) using CINtec Plus™ kit defines p16-positive NSCCUP; HR-HPV DNA, high-risk human papillomavirus-subtype DNA detected by hybridization using the Inno-LiPA HR-HPV detection kit™.
P values from Pearson’s Chi-square tests < 0.05 are in bold.