Table 1.
Effects of phendione and its metal complexes combined with amphotericin B on Phialophora verrucosa growth.
| MIC mg/L (μM) | ||||
|---|---|---|---|---|
| Agents | Alone | Combined | FIC | FICI |
| AmB | 6.2 (6.8) | 3.1 (3.4) | 0.5 | 1.0 |
| Phendione | 2.5 (12.0) | 1.2 (6.0) | 0.5 | |
| AmB | 6.2 (6.8) | 3.1 (3.4) | 0.5 | 1.0 |
| [Ag(phendione)2]+ | 2.5 (4.0) | 1.2 (2.0) | 0.5 | |
| AmB | 6.2 (6.8) | 1.5 (3.4) | 0.2 | 0.7 |
| [Cu(phendione)3]2+ | 5.0 (5.0) | 2.5 (2.5) | 0.5 | |
The type of interaction was determined by calculating the fractional inhibitory concentration (FIC) index (FICI) as described by Chudzik et al. (2019) and detailed in Material and Methods. Minimum inhibitory concentration (MIC) was defined as the lowest concentration capable of inhibiting 100% of fungal growth. AmB, amphotericin B.