Figure 2.

Overview of the role of osteocyte-specific molecules in mechanotransduction. Osteocytes are interconnected to form LCN that facilitates mechanotransduction. Pericellular matrix contributes to sensation of load-induced interstitial fluid flow. Cell processes and cilium are connected to cytoskeleton and the deformation of structure can initiate signals transmission. Gap junctions between cells are responsible for direct exchange of signaling molecules. Proteins located at the extension parts and membrane can mediate mechanotransduction through a few pathways. The expression of bone remodeling genes will be altered when adapting to the changes in mechanical environment.