Fig. 2.

m⁶A modification modulates the growth and the metastasis of breast tumor. Shown here is molecules and pathways regulated by m⁶A regulatory proteins resulting in enhanced or suppressed breast tumor growth and metastasis. Arrows indicate activation to downstream molecules or pathways, and flat lines indicate inhibition to downstream molecules or pathways. Bold arrows indicate m⁶A dependent manner, dashed lines indicate m⁶A independent manner, and solid arrows or lines indicate unknown manner. Red arrows or flat lines indicate to enhance breast tumor growth and metastasis, blue arrows or flat lines indicate to suppress breast tumor growth and metastasis. The red box means high expression, the blue box means low expression, and the gray box means unreported expression in breast cancer. “?”, unknown mechanism. (Color version of figure is available online.)