Table 6.
Functional visual network connectivity related to improved Rey-Osterrieth Complex Figure Test copy task scores after virtual reality cognitive training.
| Seed and connected regions (voxels) | Clusters | |||
|
|
Voxel (2×2×2) | MNIa coordinates (x, y, z)b | FDRc–corrected P valued | |
| Visual lateral, Re | 291 | –06, +40, +42 | .003 | |
|
|
Paracingulate gyrus, Lf | 118 |
|
|
|
|
Paracingulate gyrus, R | 68 |
|
|
|
|
Frontal pole, L | 41 |
|
|
|
|
Superior frontal gyrus, L | 29 |
|
|
|
|
Anterior cingulate gyrus | 7 |
|
|
|
|
Frontal pole, R | 1 |
|
|
|
|
White matter | 27 |
|
|
| Visual medial | 719 and 401 | +16, +20, +16 and –22, +22, +16 | <.001 and <.001 | |
|
|
Insular cortex, R | 71 |
|
|
|
|
Frontal pole, R | 48 |
|
|
|
|
Frontal operculum cortex, R | 25 |
|
|
|
|
Caudate, R | 24 |
|
|
|
|
Caudate, L | 3 |
|
|
|
|
Putamen, R | 2 |
|
|
|
|
White matter | 546 |
|
|
|
|
Insular cortex, L | 2 |
|
|
|
|
White matter | 399 |
|
|
| Visual lateral, L | N/Ag | N/A | N/A | |
| Visual occipital | N/A | N/A | N/A | |
aMNI: Montreal Neurological Institute.
bCoordinates indicate the representative coverage region with maximum power among all connected regions.
cFalse-discovery Rate.
dGroup-level analyses between the VR and control groups were performed using a general linear model with Rey-Osterrieth Complex Figure Test copy task improvement as an explanatory variable and the post-pre training z transformation value as a dependent variable after adjusting for age, years of education, sex, Clinical Dementia Rating-Sum of Boxes, depressive symptoms, and pharmacotherapy.
eR: right side.
fL: left side.
gN/A: not applicable.