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Design of clickable and photoactivable pregnenolone (P5) probes
(A) Schematic diagram of our chemoproteomic approach to pull down the P5-interacting proteome in live cells.
(B) Synthesis of the photoactivatable and clickable linker with diazirine and alkyne.
(C) Final chemical structures of the four different probes with their linker positions as compared with the mother molecule P5.
