Fig 3.

NAFLD xenograft mouse livers show altered metabolic profile after 12 weeks on WD.

Global metabolic profiles were determined in livers of 12 week WD or NC chimeric mice (n = 8 per group). (A) Metabolite species increased in livers of NAFLD xenograft mice after 12 weeks of WD. (B) Metabolite species decreased in livers of NAFLD xenograft mice after 12 weeks on WD. (C) Relative levels of individual metabolites are shown. FA, fatty acid; NAFLD, non-alcoholic fatty liver disease; NC, normal chow; PUFA, polyunsaturated fatty acid; WD, Western-type diet.