Fig 4.

Altered lipid profile in livers of NAFLD xenograft mice.

Global lipid profiles were determined in livers of 12-week WD or NC chimeric mice (n = 8 per group). (A) Hepatic levels of lipids. ∗p <0.05, ∗p <0.01, and ^∗∗∗p <0.001 using Welch's t-test. (B) Hepatic fatty acyl composition (relative to NC-fed humanised mice). Grey boxes, data not available. CE, cholesteryl ester; CER, ceramide; DAG, diacylglycerol; DCER, dihydroceramide; FFA, free fatty acid; HCER, hexosylceramide; LCER, lactosylceramide; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; MAG, monoacylglycerol; NAFLD, non-alcoholic fatty liver disease; NC, normal chow; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; TAG, triacylglycerol; WD, Western-type diet.