Fig 5.

Divergent transcriptional responses to WD between CHHs and CMHs in NAFLD xenograft mice.

Transcriptomic analysis of human (A and B) and mouse (C and D) hepatocytes was performed in livers of 12 week WD or NC chimeric mice (n = 8 per group). Upregulated genes in the WD-fed mice relative to the NC group are shown in red, downregulated genes are in blue. (D) Groupwise comparison of differentially expressed mouse and human genes (WD vs. NC). CHHs, chimeric human hepatocytes; CMHs, chimeric mouse hepatocytes; NC, normal chow; NAFLD, non-alcoholic fatty liver disease; WD, Western-type diet.