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. 2021 May 13;14(8):101100. doi: 10.1016/j.tranon.2021.101100

Fig. 4.

Fig. 4

OLFML2A is a target gene of AP-1 transcription factor A. Venn diagram showing the overlap between c-Jun knockdown and transfection with T-5224 or fra-1 knockdown and transfection with T-5224 in the BT549 cells; B. Heatmap showing the top 10 differentially expressed genes in 136 overlapped genes; C. GO analysis of 136 overlapped genes including the top 10 differentially expressed genes; D. Expression level of OLFML2A was associated with prognosis of ER-negative breast cancer patients; E. Expression level of OLFML2B was associated with prognosis of ER-negative breast cancer patients; F. Correlation between the expression of OLFML2A and c-Jun; G. Binding region of c-Jun or Fra-1 in the OLFML2A gene of CHIP-seq from research of Zhao et al. in the Cistrome Data Browser database; H. Binding region of c-Jun in the OLFML2A gene of CHIP-seq from research of Qiao et al. in the Cistrome Data Browser database; I: ChIP-PCR analysis confirms the recruitment of Fra-1 and c-Jun to OLFML2A.