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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Ann N Y Acad Sci. 2019 Aug 18;1460(1):43–56. doi: 10.1111/nyas.14208

Fig.3. Recombinant PGRN promotes diabetic bone fracture healing by inhibiting inflammation.

Fig.3

(A) Recombinant PGRN significantly enhanced diabetic bone regeneration in WT mice subjected to the femoral segmental bone defect model, assayed by X-ray. Residual gap size was quantified based on radiology results. (B) HE staining of PBS- and PGRN-treated diabetic drill-hole model. Black arrows indicate bone gap. (C) Expression and quantification of NOS-2 in callus of PBS-/PGRN-treated diabetic drill-hole model mice assayed by Western blot and ImageJ program. (D-F) Transcriptional levels of IL-1β, NOS-2 and COX-2 from the callus of drill-hole model. Each group contained 10 mice. Student’s t-test was used for the statistical analysis. The values are the mean ±SD. *p < 0.05 and ***p < 0.001 vs. control group.