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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Ann N Y Acad Sci. 2019 Aug 18;1460(1):43–56. doi: 10.1111/nyas.14208

Fig.4. Recombinant PGRN promotes diabetic bone fracture healing by accelerating chondrogenesis.

Fig.4

(A) Safranin O staining of Bonnarens and Einhorn model in diabetic bone fracture healing at various time points. (B) Quantification of bony bridging analysis based on the Safranin O staining. Each group contained 10 mice. Two way ANOVA was used for the statistical analysis. (C-D) Transcriptional levels of Collagen II (Col II) and aggrecan (ACN) in PBS-/PGRN- treated diabetic callus on Day 10. Student’s t-test was used for the statistical analysis. The values are the mean ±SD. **p < 0.01 and ***p < 0.001 vs. control group.