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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Ann N Y Acad Sci. 2019 Aug 18;1460(1):43–56. doi: 10.1111/nyas.14208

Fig.6. PGRN promotes chondrogenesis through TNFR2-Akt/Erk1/2/mTOR signaling.

Fig.6

(A&B) Primary mouse bone marrow cells of WT, TNFR1−/− and TNFR2−/− mouse were cultured with or without PGRN (200 ng/ml) for 6 hours, transcriptional levels of type II collagen (Col II) and aggrecan (ACN) were determined by Real-time PCR assay. The values are the mean ±SD. **p < 0.01 and ***p < 0.001 vs. control group. Two-way ANOVA was used for the statistical analysis. (C) Primary mouse bone marrow cells of WT mice were incubated in presence of PGRN, and phosphorylation of the indicated signaling molecules were determined by cocktail scanning. (D) A proposed model for the role of PGRN in diabetic bone fracture healing process.