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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Ann N Y Acad Sci. 2021 Feb 4;1490(1):77–89. doi: 10.1111/nyas.14568

Figure.4. PGRN promotes chondrogenesis in T2DM.

Figure.4

(A) Immunohistochemical staining of type 2 collagen in the callus collected from Bonnarens and Einhorn fracture mice on day 10 post-surgery. Positive signal is indicated in brown. Transcriptional levels of COL2A1 (type II collagen) and ACAN (aggrecan) in (B,C) the callus of Bonnarens and Einhorn fracture mice on day 10 post-surgery and (D,E) in primary bone marrow cells of FVB and MKR mice in absence or presence of recombinant PGRN, as determined by reverse transcriptase-polymerase chain reaction. The values shown represent the mean ± standard deviation of three independent experiments. *p < 0.05 and ** p < 0.01 vs. control group.