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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Ann N Y Acad Sci. 2021 Feb 4;1490(1):77–89. doi: 10.1111/nyas.14568

Figure.6. PGRN promotes chondrogenic gene expression in bone marrow cells from T2DM mice via TNFR2-Akt and Erk1/2 signaling in T2DM.

Figure.6

(A, B) Transcriptional expression of COL2A1 (type II collagen) and ACAN (aggrecan) in primary bone marrow cells from MKR mice in the absence or presence of recombinant PGRN with TNFR1 or TNFR2 antibody. (C) Primary FVB and MKR mouse bone marrow cells were incubated with PGRN, and activation of signaling molecules were examined by cocktail antibody scanning. (D) Activation of the indicated signaling molecules was assayed by cocktail scanning in the presence of TNFR1 or TNFR2 antibody in primary MKR bone marrow cells. The values shown represent the mean ± standard deviation. *p < 0.05 and ** p < 0.01 vs. control group.