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Performance assessment via simulation studies. Seven circadian rhythm detection methods are evaluated under different experimental designs to explore how sampling patterns, replicates, waveforms, SNRs, uneven samplings and missing values affect performance. Simulations under each design are carried out with different sampling frequencies: (A) 4 h/1 day, (B) 3 h/1 day and (C) 2 h/1 day. AUC values calculated from ground truths are used as metrics.
