Table 2.
G-loop residues with multiple variants
| Kinase | G-loop mutations | Kinase | G-loop mutations |
|---|---|---|---|
| ABL1 | L248R/V/_K274del, G250E/R, | IKBKB | R31*/X |
| G251C/D/E, Q252E/H/K/M/P/R, | KDR | R842C/L | |
| Y253C/F, E255D/K/L/V | MAP2K1 | G80S/D | |
| BMPR2 | R211*/P/Q/X, R213*/X, Y214*/X | MAP2K4 | R110*/P/X/Q |
| BRAF | G464E/R/V, G466A/E/R/V/X | MAP4K4 | G37*/X |
| S467F/L, F468C/L/S | MARK2 | G62C/S | |
| G469A/del/E/R/S/V/X, V471A/I/F | MAPK9 | G35E/R | |
| CDK13 | I711L/V | MYLK4 | R116C/H, Q119*/R |
| CDK2 | G13C/D/S | NTRK2 | E546*/K/V |
| CLK2 | R176*/X | PRKACA | S54F/Y |
| CSNK1A1 | S27C/F | PRKCB | S352N/G, F353L/E |
| DAPK1 | A25P/V | ROCK2 | G104R/V |
| DDR1 | E618K/Q | ROS1 | Y1960*/H |
| EGFR | G719A/C/D/S/V, S720C/F/P/T | SGK1 | L113F/P |
| G721A/D/S/V/W, F723L/S | STK11 | G56GS?/V/W, Y60*/I?, K62*/X | |
| G724D/S, T725A/M | STK26 | S34*/X | |
| EPHA2 | G620E/R | STK4 | V44A/I |
| EPHA3 | G633E/R | TGFBR1 | G212D/V, R215*/G/X/P |
| EPHA7 | I639F/T, G642A/E | TNIK | G34R/V |
| EPHA8 | G647E/R | TNK2 | G135D/S |
| EPHB4 | E625K/Q | VRK2 | G38E/R |
| FLT3 | G617E/V, S618L/_G619ins21 | ||
| A620_F621ins35/39/58/66 | |||
| G622R/_K623ins31 |
Note: Among the 147 kinases that harbor G-loop mutations, 37 had multiple variants on a G-loop residue.