Table 3.
αC-helix residues with multiple variants
| Kinase | Mutations | Kinase | Mutations |
|---|---|---|---|
| ABL1 | E282K/G/V, V289A/F/M | GRK4 | I223K/T |
| AKT1 | V185A/D | GSG2 | S539F/P |
| AKT2 | A190G/T | IKBKB | R53Q/W |
| ALK | M1166R/>?, E1167A/K, I1170N/S/T, I1171N/S/T | IRAK4 | Q232*/X |
| AURKB | Q112*/H | ITK | M411L/V |
| BRAF | TAPTP488/K, K499N/Q | JAK1 | R629K/_D630del, Q644*/H |
| BUB1 | P828R/S | JAK2 | G571R/S, E890*/D, D894E/G |
| CAMK2B | R66H/C | JAK3 | R870W/Q |
| CAMK4 | L93F/I/R | KDR | R880*/Q/X |
| CDK5 | R50L/Q/W | KIT | R634Q/W, L637F/H/P, K642E/N/Q, |
| CDK8 | R71*/G | Y646H/D, L647F/P | |
| CDKL3 | E50*/X | LYN | E290D/K |
| CDKL5 | R59*/Q | MAP2K2 | Q114*/H |
| CDK12 | R773C/H | MAP2K4 | E141*/K, Q142/L, L146F/P, D148/Y |
| CLK2 | E213A/Q | MAP2K7 | R162H/C |
| CSNK1A1 | E60*/K | MAPK13 | Y70C/H |
| CSNK2A1 | R80C/H | MAPKAPK3 | K80*/N/X, Q90E/P |
| CSNK2A2 | K77M/N | MARK1 | R106*/X |
| DAPK1 | R58C/H | MARK2 | V106A/L |
| DYRK1A | R205*/X | MASTL | S120F/P |
| DYRK2 | R274Q/W | MERTK | C640F/X |
| EGFR | E758D/G/K, E749_E758 > QP, | NEK7 | R76C/L/H |
| A750_E758del/delATSPKANKE/P, | NTRK3 | D584E/N, E590D/K | |
| A750_I759 > GS/PT, | PAK1 | Q304*/X | |
| T751_E758 > A/del/delTSPKANKE, | PDGFRA | L641I/V | |
| T751_I759 > AC/del/>N/>NKA/>REA/>S, | PHKG2 | R75Q/W, R82C/H | |
| S752_I759del/delSPKANKEI, | PRKAA2 | R53C/H | |
| N756S/Y/_L760del, K757M/N/R, | PRKCB | V378E/M | |
| I759N/V, D761G/N/Y, D761_E762insEAFQ, | PRKCH | D394G/V | |
| A763D/V, Y764S/_V765insHH, | PRKCI | E288*/Q | |
| V765G/M/_M766insMAS, | ROS1 | M2001T/L | |
| A767V/AAWT/_S768insSVG/_S768insYVM | PTK2B | E474K/Q | |
| EIF2AK2 | E303K/V | ROCK1 | K109E/I |
| EIF2AK3 | R633L/Q/W | RPS6KA3 | R110*/Q/X, E463K/V |
| EPHA5 | R718C/H, D720E/H/Y | STK11 | K84*/X, R86G/X |
| EPHA7 | D678E/N, S684I/R | STK17B | H79N/R |
| EPHA8 | A685G/T/V | STK3 | S72F/P |
| EPHB1 | R663L/Q/W | STK32A | E61*/X |
| ERBB2 | D769H/N/Y, V773A/M | TNNI3K | R508*/8Q, L513F/I/P |
| FLT3 | K663N/Q/R | ZAP70 | T380K/M, E386K/Q, Q388H/L |
Note: Among the 181 kinases that harbor αC-helix mutations, 69 had multiple variants on a αC- helix residue.