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. 2020 Jun 2;22(3):bbaa072. doi: 10.1093/bib/bbaa072

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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External data contributing to selection of 1000 genes. Close to 1000 genes were selected by the CMap successor, LINCS, to represent drug responses. The FocusHeuristics (``Focus'') reduces gene interaction networks on the basis of gene expression changes, here run with parameters to also yield a reduction to 1000 genes. These filters are shown in the context of the Pearson and similarity scores. The ‘same dir’ scoring function counts the number of genes changing to the same direction with a log ratio > 0.5 in both instances.

Inline graphic — External data contributing to selection of 1000 genes. Close to 1000 genes were selected by the CMap successor, LINCS, to represent drug responses. The FocusHeuristics (``Focus'') reduces gene interaction networks on the basis of gene expression changes, here run with parameters to also yield a reduction to 1000 genes. These filters are shown in the context of the Pearson and similarity scores. The ‘same dir’ scoring function counts the number of genes changing to the same direction with a log ratio > 0.5 in both instances.