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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Neuron. 2016 Sep 1;91(6):1342–1355. doi: 10.1016/j.neuron.2016.08.008

Figure 4. Characteristics of Pyramidal Cells in CA1, CA2, and CA3 Regions.

Figure 4.

(A) Percentage of cells per region that significantly increased or reduced their firing rates during CA1 SPW-R. Bottom part of each bar represents positively modulated percent of cells, middle part (black or dark green) represents negatively modulated cells, and gray represents non-modulated cells. Note that while only a minority of cells is suppressed in most regions (black), approximately half of the CA2 pyramidal cells reduce their firing rates during SPW-Rs (dark green).

(B) Median firing rates (boxes, interquartile ranges; error bars, ranges) of CA1, CA2, and CA3 pyramidal cells during SLEEP and WAKE. CA2 pyramidal cells fired faster in both states compared to CA1 and CA3 (p < 0.01/0.001 for all comparisons during SLEEP and WAKE, Wilcoxon rank-sum test).

(C) While CA1 and CA3 pyramidal cells fired more during SLEEP than WAKE, CA2 principal cells showed the opposite behavior.

Error bars represent ±SEM. See also Figure S3.