Table 2.
Analysis of outcomes
| 2–5 day regimen | 14-day regimen | p-value | |
|---|---|---|---|
| n = 474 | n = 155 | ||
| Primary outcome measure | |||
| Days alive and out of hospital within 14 days, Mean (95% CI) | 8.3 (7.9–8.7) | 4.2 (3.6–4.9) | < 0.001 |
| Secondary outcome measures | |||
| Cumulative median dose corticosteroids (mg) | |||
| over 6-month follow-up period (IQR) | 322.5 (200–605) | 560 (560–773) | |
| Death during 6-month follow-up period | |||
| Adjusted HR (95% CI)a | Reference | 0.8 (0.4–1.5) | 0.45 |
| Death or admission to ICU during 6-month follow-up period | |||
| Adjusted OR (95% CI)b | Reference | 1.4 (0.9–2.3) | 0.25 |
| New or aggravated hypertensionb | |||
| Adjusted OR (95% CI) | Reference | 1.5 (0.9–2.7) | 0.15 |
| Length of hospital stayc | |||
| Adjusted mean days (SE) | Reference | + 5.4 (± 0.6) | < 0.0001 |
| Probability of discharge within 30 daysa | |||
| Adjusted HR (95% CI) | Reference | 0.6 (0.5–0.70) | < 0.0001 |
CI confidence interval, HR hazard ratio, OR odds ratio, ICU intensive care unit, SE standard error
aBased on Cox proportional hazards model adjusted for age, sex, smoking status, pre-treatment with antibiotics, pre-treatment with corticosteroids, and Medical Research Council dyspnoea scale
bBased on logistic model adjusted for age, sex, smoking status, pre-treatment with antibiotics, pre-treatment with corticosteroids, and Medical Research Council dyspnoea scale
cBased on means and standard error