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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Cell Rep. 2021 May 4;35(5):109074. doi: 10.1016/j.celrep.2021.109074

Figure 1. A single episode of ELS increases the synaptic excitation-to-inhibition ratio.

Figure 1.

(A) Schematic of adeno-associated virus (AAV) injection and experimental timeline.

(B) Images of dendrites from layer 2/3 pyramidal neurons from the PFC and SSC of control and ELS mice.

(C) Summary graph of spine density in vivo (control, 27 cells, 6 mice; ELS, 25 cells, 5 mice) and in vitro (control, 18 cells, 4 mice; ELS, 18 cells, 4 mice) in the PFC and SSC (control, 10 cells, 3 mice; ELS, 11 cells, 3 mice).

(D) Quantitative analysis of the estimated spine size and spine length-to-width ratio (control, 18 cells, 4 mice; ELS, 18 cells, 4 mice).

(E) Representative traces of mEPSCs and mIPSCs.

(F) Quantification of the frequency (left) and amplitude (right) of mEPSCs in control (14 cells, 3 mice) and ELS (15 cells, 3 mice) mice.

(G) Summary graph of mIPSC frequency (left) and amplitude (right) in control (14 cells, 4 mice) and ELS (15 cells, 4 mice) mice.

**p < 0.01. Error bars represent SEM. n.s., not significant.