TABLE 3.

Differences in Natriuretic Peptide Levels Between Lean and Obese Individuals

	24-h Natriuretic Peptide Level Differences
	Lean	Obese, β (95% CI)	% Difference (95% CI)*	p Value
Log MR-proANP
24-h MR-proANP	Ref.	−0.30 (−0.52 to −0.08)	−25.9 (−40.5 to −7.7)	0.008
Daytime MR-proANP	Ref.	−0.33 (−0.55 to −0.11)	−28.1 (−42.3 to −10.4)	0.004
Nighttime MR-proANP	Ref.	−0.26 (−0.50 to −0.03)	−22.9 (−39.3 to −3.0)	0.03
Log BNP
24-h BNP	Ref.	−0.38 (−0.65 to −0.11)	−31.6 (−47.8 to −10.4)	0.01
Daytime BNP	Ref.	−0.38 (−0.67 to −0.09)	−31.6 (−48.8 to −8.6)	0.02
Nighttime BNP	Ref.	−0.37 (−0.64 to −0.10)	−30.9 (−47.3 to −9.5)	0.01
Log NT-proBNP
24-h NT-proBNP	Ref.	−0.67 (−1.18 to −0.17)	−48.8 (−69.3 to −15.6)	0.01
Daytime NT-proBNP	Ref.	−0.67 (−1.18 to −0.16)	−48.8 (−69.3 to −14.8)	0.01
Nighttime NT-proBNP	Ref.	−0.69 (−1.18 to −0.20)	−49.8 (−69.3 to −18.1)	0.01

^*Adjusted for age, sex, and race. Multivariable linear regression models using natural log-transformed NP as the dependent variable and race as the independent variable was used to assess statistical difference by obesity. Lean individuals were chosen as reference. Values shown were β coefficient (95% confidence interval [CI]), which were on the log NP scale. Percentage lower than lean was the estimated % difference in NP levels in lean vs. obese, which was calculated by using the formula (e^β − 1) × 100, assuming all other variables in the model remained constant.

Abbreviations as in Table 1.