Figure 4.
(A) Characterization of lysine hydroxylase GlbB and selected substrate scope. (B) Nine-step total synthesis of cepafungin I empowered by lysine hydroxylation with GlbB. (C) PSMB5 inhibitory assay results with synthetic analogues of 38.
(A) Characterization of lysine hydroxylase GlbB and selected substrate scope. (B) Nine-step total synthesis of cepafungin I empowered by lysine hydroxylation with GlbB. (C) PSMB5 inhibitory assay results with synthetic analogues of 38.