Table 2.
Replicated results of the proteome-wide analysis of prevalent MetS in KORA and HUNT, sorted by the magnitude of the OR in KORA
| Protein full name | UniProt | Gene symbol | KORA (n = 998) | HUNT (n = 923) | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |||
| Leptin | P41159 | LEP | 3.70 (2.95–4.70) | 4.77E-28 | 1.76 (1.49–2.08) | 3.76E−11 |
| Plasminogen activator inhibitor 1 | P05121 | SERPINE1 | 2.51 (2.12–3.00) | 2.24E−25 | 1.37 (1.19–1.57) | 9.99E−06 |
| Growth hormone receptor | P10912 | GHR | 2.33 (1.97–2.78) | 3.84E−22 | 2.08 (1.76–2.47) | 9.44E−18 |
| Tissue-type plasminogen activator | P00750 | PLAT | 2.17 (1.82–2.61) | 1.54E−17 | 1.36 (1.19–1.57) | 8.57E−06 |
| Aminoacylase-1 | Q03154 | ACY1 | 2.16 (1.83–2.56) | 2.95E−19 | 1.93 (1.64–2.30) | 2.71E−14 |
| Dickkopf-like protein 1 | Q9UK85 | DKKL1 | 1.96 (1.63–2.39) | 6.02E−12 | 1.31 (1.15–1.51) | 9.54E−05 |
| Galectin-3-binding protein | Q08380 | LGALS3BP | 1.85 (1.59–2.16) | 3.66E−15 | 1.52 (1.32–1.75) | 6.81E−09 |
| GDNF family receptor alpha-1 | P56159 | GFRA1 | 1.78 (1.52–2.09) | 7.06E−13 | 1.46 (1.27–1.70) | 1.99E−07 |
| Complement factor H | P08603 | CFH | 1.76 (1.51–2.06) | 1.44E−12 | 1.67 (1.42–1.98) | 7.71E−10 |
| Apolipoprotein E (isoform E3) | P02649 | APOE | 1.73 (1.49–2.02) | 1.17E−12 | 1.47 (1.26–1.72) | 1.16E−06 |
| Retinoic acid receptor responder protein 2 | Q99969 | RARRES2 | 1.72 (1.48–2.01) | 3.04E−12 | 1.54 (1.33–1.80) | 1.84E−08 |
| Endoplasmic reticulum resident protein 29 | P30040 | ERP29 | 1.71 (1.46–2.00) | 1.39E−11 | 1.40 (1.21–1.61) | 3.97E−06 |
| Complement factor I | P05156 | CFI | 1.70 (1.46–2.00) | 1.81E−11 | 1.36 (1.18–1.58) | 2.72E−05 |
| Proto-oncogene tyrosine-protein kinase receptor | P07949 | RET | 1.70 (1.46–1.99) | 1.19E−11 | 1.87 (1.59–2.21) | 1.71E−13 |
| Bone morphogenetic protein 1 | P13497 | BMP1 | 1.68 (1.44–1.97) | 8.25E−11 | 1.40 (1.17–1.68) | 2.66E−04 |
| Afamin | P43652 | AFM | 1.66 (1.43–1.93) | 4.89E−11 | 1.37 (1.19–1.58) | 1.28E−05 |
| Reticulon-4 receptor | Q9BZR6 | RTN4R | 1.65 (1.42–1.92) | 7.45E−11 | 1.65 (1.42–1.92) | 6.57E−11 |
| Scavenger receptor cysteine-rich type 1 protein M130 | Q86VB7 | CD163 | 1.59 (1.38–1.85) | 5.75E−10 | 1.41 (1.23–1.62) | 8.61E−07 |
| C–C motif chemokine 25 | O15444 | CCL25 | 1.57 (1.36–1.82) | 1.04E−09 | 1.33 (1.15–1.53) | 7.50E−05 |
| E-selectin | P16581 | SELE | 1.56 (1.34–1.82) | 1.29E−08 | 1.68 (1.45–1.94) | 3.29E−12 |
| Ficolin-3 | O75636 | FCN3 | 1.52 (1.30–1.77) | 1.15E−07 | 1.31 (1.13–1.52) | 3.72E−04 |
| Lysosomal protective protein | P10619 | CTSA | 1.51 (1.31–1.76) | 4.55E−08 | 1.29 (1.12–1.49) | 4.00E−04 |
| Cathepsin Z | Q9UBR2 | CTSZ | 1.49 (1.29–1.73) | 9.24E−08 | 1.42 (1.24–1.65) | 1.35E−06 |
| Thrombospondin-2 | P35442 | THBS2 | 1.43 (1.24–1.65) | 7.57E−07 | 1.38 (1.20–1.60) | 1.33E−05 |
| C–C motif chemokine 16 | O15467 | CCL16 | 1.42 (1.21–1.68) | 3.69E−05 | 1.34 (1.16–1.55) | 5.95E−05 |
| Insulin-like growth factor-binding protein 2 | P18065 | IGFBP2 | 0.33 (0.27–0.39) | 4.63E−33 | 0.52 (0.44–0.62) | 4.04E−14 |
| Sex hormone-binding globulin | P04278 | SHBG | 0.42 (0.35–0.50) | 6.47E−22 | 0.47 (0.40–0.56) | 2.86E−18 |
| Insulin-like growth factor-binding protein 1 | P08833 | IGFBP1 | 0.43 (0.37–0.51) | 1.03E−23 | 0.55 (0.47–0.64) | 1.98E−14 |
| Endothelial cell-specific molecule 1 | Q9NQ30 | ESM1 | 0.47 (0.39–0.56) | 1.20E−16 | 0.68 (0.57–0.80) | 1.31E−05 |
| Netrin receptor UNC5D | Q6UXZ4 | UNC5D | 0.48 (0.40–0.56) | 8.72E−18 | 0.75 (0.64–0.87) | 1.92E−04 |
| WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 | Q8TEU8 | WFIKKN2 | 0.48 (0.41–0.57) | 2.52E−18 | 0.65 (0.56–0.75) | 3.52E−09 |
| Brevican core protein | Q96GW7 | BCAN | 0.50 (0.42–0.59) | 4.72E−15 | 0.61 (0.51–0.73) | 1.87E−07 |
| Neural cell adhesion molecule 1, 120 kDa isoform | P13591 | NCAM1 | 0.51 (0.44–0.60) | 6.01E−17 | 0.63 (0.54–0.73) | 1.10E−09 |
| Tumor necrosis factor-inducible gene 6 protein | P98066 | TNFAIP6 | 0.51 (0.44–0.60) | 2.05E−15 | 0.65 (0.56–0.75) | 5.30E−09 |
| Wnt inhibitory factor 1 | Q9Y5W5 | WIF1 | 0.52 (0.43–0.62) | 2.39E−12 | 0.76 (0.66–0.88) | 1.62E−04 |
| Hepatocyte growth factor receptor | P08581 | MET | 0.52 (0.44–0.60) | 1.22E−16 | 0.73 (0.63–0.85) | 4.76E−05 |
| Osteomodulin | Q99983 | OMD | 0.53 (0.45–0.62) | 2.38E−14 | 0.75 (0.65–0.87) | 1.21E−04 |
| Transforming growth factor beta receptor type 3 | Q03167 | TGFBR3 | 0.53 (0.45–0.62) | 9.27E−16 | 0.72 (0.62–0.84) | 1.78E−05 |
| Mast/stem cell growth factor receptor Kit | P10721 | KIT | 0.56 (0.47–0.65) | 9.54E−13 | 0.74 (0.64–0.86) | 5.65E−05 |
| Gelsolin | P06396 | GSN | 0.57 (0.49–0.67) | 1.83E−12 | 0.66 (0.57–0.76) | 3.50E−08 |
| Iduronate 2-sulfatase | P22304 | IDS | 0.59 (0.51–0.69) | 2.21E−11 | 0.76 (0.65–0.87) | 1.70E−04 |
| 72 kDa type IV collagenase | P08253 | MMP2 | 0.60 (0.51–0.69) | 2.09E−11 | 0.64 (0.56–0.74) | 3.08E−09 |
| Neural cell adhesion molecule L1-like protein | O00533 | CHL1 | 0.60 (0.51–0.69) | 2.41E−11 | 0.73 (0.63–0.83) | 6.26E−06 |
| Epidermal growth factor receptor | P00533 | EGFR | 0.60 (0.51–0.70) | 7.17E−11 | 0.73 (0.62–0.86) | 2.28E−04 |
| Interleukin-1 Receptor accessory protein | Q9NPH3 | IL1RAP | 0.60 (0.51–0.70) | 1.61E−10 | 0.71 (0.62–0.82) | 1.61E−06 |
| Apolipoprotein B | P04114 | APOB | 0.60 (0.52–0.69) | 9.93E−12 | 0.77 (0.67–0.88) | 1.66E−04 |
| Neurogenic locus notch homolog protein 1 | P46531 | NOTCH1 | 0.61 (0.52–0.70) | 4.64E−11 | 0.77 (0.67–0.88) | 1.63E−04 |
| Plasma protease C1 inhibitor | P05155 | SERPING1 | 0.61 (0.53–0.71) | 3.89E−11 | 0.66 (0.56–0.77) | 1.80E−07 |
| Chordin-like protein 1 | Q9BU40 | CHRDL1 | 0.67 (0.57–0.79) | 2.86E−06 | 0.72 (0.60–0.86) | 4.50E−04 |
| Thrombin | P00734 | F2 | 0.68 (0.57–0.81) | 2.65E−05 | 0.65 (0.55–0.75) | 4.13E−08 |
| Kallikrein-8 | O60259 | KLK8 | 0.72 (0.62–0.83) | 5.94E−06 | 0.79 (0.69–0.90) | 4.12E−04 |
| Superoxide dismutase [Mn], mitochondrial | P04179 | SOD2 | 0.73 (0.63–0.84) | 2.42E−05 | 0.74 (0.64–0.85) | 3.13E−05 |
| Muellerian-inhibiting factor | P03971 | AMH | 0.74 (0.64–0.85) | 4.28E−05 | 0.77 (0.66–0.88) | 4.05E−04 |
All analyses were adjusted for age, sex, smoking status and physical activity
OR; odds ratio per 1 SD increase in log-transformed protein levels