Table 2.
The association of MTNR1B SNPs with BMI and waist circumference
| BMI | Waist circumference | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | BP | A1 | A2 | MAF | p value | FDR p value | Beta | SE (Beta) | p value | FDR p value | Beta | SE (Beta) | Type of Mutation |
| rs3781638 | 92980341 | T | G | 0.499 | 0.0041 | 0.0200 | −0.0158 | 0.0055 | 0.0006 | 0.0075 | −0.0140 | 0.0041 | Intronic |
| rs1562444 | 92982683 | A | G | 0.446 | 0.0056 | 0.0200 | −0.0153 | 0.0055 | 0.0007 | 0.0075 | −0.0138 | 0.0041 | 3'-UTR |
| rs12792653 | 92982750 | A | G | 0.446 | 0.0056 | 0.0200 | −0.0153 | 0.0055 | 0.0008 | 0.0075 | −0.0138 | 0.0041 | 3'-UTR |
| rs8192552 | 92969796 | G | A | 0.094 | 0.0432 | 0.0925 | 0.0189 | 0.0094 | 0.0010 | 0.0077 | 0.0228 | 0.0069 | Missense |
| rs6483209 | 92976223 | C | T | 0.212 | 0.0025 | 0.0200 | −0.0201 | 0.0067 | 0.0020 | 0.0089 | −0.0153 | 0.0050 | Intronic |
| rs12290860 | 92979012 | G | A | 0.224 | 0.0060 | 0.0200 | −0.0184 | 0.0067 | 0.0017 | 0.0089 | −0.0155 | 0.0049 | Intronic |
| rs7127128 | 92980510 | A | G | 0.227 | 0.0029 | 0.0200 | −0.0196 | 0.0066 | 0.0024 | 0.0089 | −0.0149 | 0.0049 | Intronic |
| rs6483210 | 92981429 | C | T | 0.227 | 0.0029 | 0.0200 | −0.0197 | 0.0066 | 0.0025 | 0.0089 | −0.0148 | 0.0049 | Intronic |
| rs61747139 | 92981951 | A | G | 0.227 | 0.0030 | 0.0200 | −0.0196 | 0.0066 | 0.0027 | 0.0089 | −0.0147 | 0.0049 | Missense |
| rs10765576 | 92973778 | G | A | 0.489 | 0.0332 | 0.0831 | −0.0117 | 0.0055 | 0.0038 | 0.0096 | −0.0117 | 0.0040 | Intronic |
| rs11020127 | 92974394 | C | A | 0.495 | 0.0050 | 0.0200 | −0.0186 | 0.0067 | 0.0034 | 0.0096 | −0.0119 | 0.0041 | Intronic |
| rs12292400 | 92979446 | G | C | 0.225 | 0.0394 | 0.0909 | −0.0112 | 0.0054 | 0.0038 | 0.0096 | −0.0143 | 0.0049 | Intronic |
| rs12272268 | 92975633 | C | G | 0.252 | 0.0184 | 0.0501 | −0.0147 | 0.0063 | 0.0048 | 0.0111 | −0.0131 | 0.0046 | Intronic |
| rs7130424 | 92980527 | T | C | 0.266 | 0.0099 | 0.0298 | −0.0160 | 0.0062 | 0.0054 | 0.0116 | −0.0128 | 0.0046 | Intronic |
| rs11020126 | 92973751 | G | A | 0.181 | 0.0606 | 0.1212 | −0.0136 | 0.0072 | 0.0165 | 0.0331 | −0.0129 | 0.0054 | Intronic |
| rs11020125 | 92973378 | T | G | 0.171 | 0.0895 | 0.1679 | −0.0124 | 0.0073 | 0.0218 | 0.0409 | −0.0124 | 0.0054 | Intronic |
| rs6483208 | 92972678 | T | G | 0.22 | 0.1446 | 0.2411 | −0.0096 | 0.0066 | 0.0287 | 0.0507 | −0.0107 | 0.0049 | Intronic |
BMI for adjusted age, sex, and ancestry; Waist Circumference for adjusted age, sex, and ancestry. The associations' results are Beta, standard error (SE), and the corresponding adjusted False Discovery Rate (FDR) p value. A1 and A2 are reference allele and alternative allele; MAF is Minor Allele Frequency; BP is Base Pair