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. 2021 May 20;12:296. doi: 10.1186/s13287-021-02372-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The results of Wnt/-catenin signaling pathway analysis. a The PCR assays of Sox-9 (1), MMP-9 (2), aggrecan (3), and -catenin (4). Data are presented as the meanSD. *P<0.05 versus the control. b The results of immunofluorescence staining of the Col-II protein. c, d show the results of WB assays. Sox-9 and aggrecan showed significantly higher expression and MMP-9 and -catenin showed significantly lower expression in the SrR treatment group than in the control group. XAV-939 significantly stimulated the synthesis of Sox-9 and aggrecan, inhibited MMP-9 and -catenin expression, and induced a similar trend when SrR was added. LiCl had the opposite effect: it downregulated Sox-9 and aggrecan expression and upregulated MMP-9 and -catenin expression, and SrR could also reverse these effects. The results were similar at both the gene and protein levels