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. 2021 May 20;12:296. doi: 10.1186/s13287-021-02372-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Histological observation. a, d, and g The empty group in which the wound was not filled; b, e, and h the control group in which the wound was filled with silica nanospheres plus GelMA gel; and c, f, and i show the SrR group in which the wound was filled with SrR-loaded silica nanospheres plus GelMA gel. Toluidine blue staining (d, e, and g) and safranin O/fast green staining (g, h, and i) revealed that the SrR group had a better cartilage tissue repair effect and significantly higher ICRS-II scores than the other two groups (j). There were significant differences of ICRS-II scores between the empty group, control group, and SrR group (P<0.05)