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. 2021 May 21;21:271. doi: 10.1186/s12935-021-01884-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Circ_0000745 downregulation inhibited OSCC cell growth by decreasing the level of CCND1.a The efficiency of CCND1 overexpression was checked by western blot. In Cal-27 and SCC9 cells transfected with sh-NC+vector, sh-circ_0000745#1+vector or circ_0000745#1+CCND1, cell proliferation was monitored by (b) CCK-8 assay and (c) colony formation assay. d, eCell apoptosis and cell cycle distribution in these cells were investigated by flow cytometry assay. f The protein levels of PCNA, Cleaved-caspase 3 and CCND1 in these cells were quantified by western blot. *P<0.05, **P<0.01 and ***P<0.001