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. 2021 May 20;12:294. doi: 10.1186/s13287-021-02358-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The activation of HSCs was inhibited by hPMSC in vitro. a Representative western blot of -SMA and GAPDH of activated HSCs, in the presence of concentrated MSC medium or concentrated hPMSC culture supernatant (hPMSC secretomes). b Typical cell morphology (upper) and -SMA immunofluorescence staining (lower) of HSCs. c Expression of fibrosis-related genes in activated HSCs was determined using qRT-PCR. Relative mRNA expression was normalized to -actin and compared with the TGF-1 group. Cells from blank group were unactivated HSCs, cells from TGF-1 group were activated HSCs that induced by TGF-1, and cells from medium group or hPMSC group were activated HSCs treated with either concentrated MSC medium or hPMSC secretomes. Scale bar, 50 m. ****p < 0.0001, ***p < 0.001, **p < 0.01; *p < 0.05; ns, no significance. HSCs, hepatic stellate cells